International Max Planck Research School on Computational Methods in Psychiatry and Ageing Research (COMP2PSYCH)
The International Max Planck Research School (IMPRS) COMP2PSYCH serves as the graduate program of the Max Planck UCL Centre for Computational Psychiatry and Ageing Research. In London, the students are based at University College London (UCL); in Berlin, they are based at the MPI for Human Development and Humboldt-Universität zu Berlin.
Co-Speakers: Ulman Lindenberger, MPI for Human Development; Raymond J. Dolan, UCL
Coordinators: Silke Schäfer, MPI for Human Development; Dominique Drai, UCL
COMP2PSYCH teaches and trains concepts and methods from computer science and statistics in relation to substantive research questions in psychiatry and lifespan psychology. It was established by the Max Planck UCL Centre for Computational Psychiatry and Ageing Research in early 2016, was positively evaluated in 2020, and extended until September 2028. The IMPRS COMP2PSYCH is an IMPRS Type B according to the Max Planck Society's categorization, i.e., it is a smaller, project-based, time-limited undertaking for innovative research topics that will end after the (current) second funding period.
| Andreas M. Brandmaier | MPI for Human Development |
| Martin J. Dahl | MPI for Human Development |
| Christian Doeller | MPI for Human Cognitive and Brain Sciences |
| Ray Dolan | University College London |
| Stephen Fleming | University College London |
| Tobias Hauser | University College London |
| Ralph Hertwig | MPI for Human Development |
| Quentin Huys | University College London |
| Simone Kühn | MPI for Human Development |
| Ulman Lindenberger | MPI for Human Development |
| Aaron Peikert | MPI for Human Development |
| Tali Sharot | University College London |
| Stephanie Theves | MPI for Human Development |
| Arno Villringer | MPI for Human Cognitive and Brain Sciences |
| Markus Werkle-Bergner | MPI for Human Development |
| G. Elliott Wimmer | University College London |
COMP2PSYCH gives predoctoral students the opportunity to learn, apply, and develop computational and statistical methods that foster our understanding of individual development from childhood to old age, with an emphasis on mental illness and healthy cognitive aging. It combines and integrates training in computer science, applied mathematics and statistics, psychology, and psychiatry with the goal of enabling the students to adapt and develop computational and statistical tools according to their data-analytic and scientific needs in the fields of psychiatry and lifespan psychology. Teaching fundamental concepts in cognitive science, lifespan psychology, and psychiatry in relation to computational and statistical theories and methods creates a superior degree of synergy between fields. In addition, the students benefit from the excellent research opportunities offered at both the Berlin and London sites. Predoctoral students have been recruited from one of the disciplines relevant to the school's program, for example cognitive neuroscience, psychology, psychiatry, health science, or statistics.
During the reporting period, 11 doctoral students were active in the IMPRS COMP2PSYCH in Berlin (see Table 2). Nine worked at the MPI for Human Development: five in the Center for Lifespan Psychology (LIP), two at the Center for Environmental Neuroscience (CEN), one at the Max Planck Research Group NeuroCode (Neural and Computational Basis of Learning, Memory and Decision Making), and one at the ERC Research Group AMD (Adaptive Memory and Decision-making). In addition, two students worked at the Department of Psychology, Humboldt-Universität zu Berlin. Five successfully completed their dissertations and joined the growing group of COMP2PSYCH alumni. During the reporting period, 12 students worked on their dissertation projects in London (see https://www.imprs-comp2psych.mpg.de).
| Name | Institution | Dissertation Project |
|---|---|---|
| Manuel Arnold* | HU | Score-based approaches to heterogeneity in psychological models |
| Fabio Bauer | MPIB | Abstraction models of perception and working memory |
| Moana Beyer | MPIB | Associations between the physical environment and brain structure and function in different cohort studies |
| Moritz Ketzer | HU | Potentials and limitations of new approaches to Bayesian SEM |
| Agnieszka Kulesza | MPIB | Neuromodulation, plasticity and cognition: Unlocking their interplay across timescales |
| Anika Löwe* | MPIB | Investigating the computational role of hippocampal replay in planning and value computation |
| Zoya Mooraj | MPIB | Cross-sectional vs. longitudinal approaches to understanding the aging brain |
| Aaron Peikert* | MPIB | Towards transparency and Open Science: A principled perspective on computational reproducibility and preregistration |
| Kira Pohlmann | MPIB | Computer science methods in environmental psychology |
| Liliana Polanski* | MPIB | Computational and neural mechanisms of human exploration-exploitation behavior |
| Alexander Skowron* | MPIB | Neural variability as a marker of cognitive flexibility during learning and decision-making under uncertainty |
The three-year training program involves seminars, workshops, participation in summer schools, and collaborative supervision of research training. The focus of the Berlin site is on computational and statistical advances in studying individual differences in development from childhood to old age. Methods include structural and functional neuroimaging, computational modeling, and statistical methods for the multivariate analysis of longitudinal changes in brain and behavior. Table 3 shows the talks and workshops offered for COMP2PSYCH students during the reporting period.
| Semester | Topic | Instructor(s) |
|---|---|---|
| Winter 2022/23 | Brain network phenotype in neuropsychiatric disorders: Targeting early stage | Helen Zhou, University of Singapore |
| Trait anxiety is associated with hidden state inference during aversive reversal learning | Ondrej Zika, MPIB | |
| Measuring intelligent use of cognitive resources in online chess | Evan Russek, Princeton University | |
| How does anxiety impair computing uncertainty? | Payam Piray, University of Southern California | |
| Decomposing the motivation to exert mental effort | Amitai Shenhav, University of California, Berkeley | |
| Imaging memory consolidation in wakefulness and sleep | Monika Schönauer, Princeton University | |
| Behavioural economics of striatal dopamine release | Neir Eshel, Stanford University | |
| Neurobiological effects of antipsychotic medication in psychotic depression | Nicholas Neufeld, University of Toronto | |
| Reward-predictive state abstractions in human reinforcement learning | Alana Jaskir, New York University | |
| Artificial intelligence-based screening of electronic health records to detect individuals at risk of psychosis | Paolo Fusar-Poli, Brown University | |
| Summer 2023 | A computational account of how affective states influence economic decisions | Roeland Heerema, UCL |
| Irrational decision-making through inhibitory competition within multiple stages of processing | Konstantinos Tsetsos, University of Bristol | |
| Neural mechanism of value-based economic decisions: Examples from humans and monkeys | Leo Chi Seak, UCL | |
| Towards an explanatory empirical programme in developmental cognitive neuroscience | Anastasia Christakou, University of Reading | |
| Self—other representation in borderline personality disorder | Giles Story, UCL | |
| Emotion regulation, emotion beliefs, and adolescent mental health | Matt Somerville, UCL | |
| Tethered rationality: A model of behavior for the real world | Vinod Goel, York University | |
| The dynamic nature of procrastination | Peiyuan Zhang, MPIB | |
| Workshop "An introduction to the Julia programming language" | Aaron Peikert, MPIB | |
| Two-day scientific presentation training | Steve Weir, Freie Universität Berlin | |
| Natural language processing enables a paradigm shift in understanding aphasia: Introducing the information restoration paradigm | Neguine Rezaii, Harvard Medical School | |
| Winter 2023/24 | A cellular basis for mapping behavioural structure | Mohamady El-Gaby, University of Oxford |
| Human decision-making under computational complexity | Peter Boasserts, University of Cambridge | |
| Computational principles of real-world memory | Kenneth Norman, Princeton University | |
| Perceptions of artificial intelligence | Nadia Said, University of Tübingen | |
| Attenuated flexible behaviour through the lens of reinforcement learning across diagnoses | Lei Zhang, University of Birmingham | |
| Investigating complex dynamics of inclusion and exclusion in the Cyberball game in Borderline Personality Disorder | Paolo Ossola, University of Parma | |
| Mental health across the life course | Avshalom Caspi, King's College London | |
| Towards naturalistic representation learning in health and disease | Angela Radulescu, Icahn School of Medicine at Mount Sinai | |
| Causality in mind: Learning, reasoning and blaming | David Lagnado, UCL | |
| Moodeling: A neuro-computational assessment of mood fluctuations and their impact on decision-making | Fabien Vinckier, Université de Paris | |
| Human cognition of geometric shapes: A window into the mental representation of abstract concepts | Mathias Sable-Meyer, UCL | |
| Computational network models for flexible decision making in health and disease | Nuttida Rungratsameetaweemana, Columbia University | |
| Steering by the torch of chaos and doubt | Charley Wu, University of Tübingen | |
| Two-day workshop "Good scientific practice" | Roland Bluhm | |
| A recurrent network model of planning predicts hippocampal replay and human behaviour | Marcelo Mattar, New York University | |
| Spectral graph theory: An introduction and some applications | Francesco Vigano, Imperial College London | |
| Summer 2024 | Staying afloat on Neurath's boat | Neil Bramley, University of Edinburgh |
| Leveraging brain-based predictive models to understand the neural underpinnings of psychiatric risk | Elvisha Dhamala, Feinstein Institutes for Medical Research | |
| Addressing two classic debates in cognitive science with AI | Brenden Lake, New York University | |
| Functional and dynamic characteristics of neuronal assemblies explored via EEG and graph theory: from healthy aging to neurodegenerative dementias | Paolo Rossini, Università Cattolica del Sacro Cuore | |
| Approaching perceptual choices as internal actions | Shervin Safavi, MPI for Biological Cybernetics, Tübingen | |
| Progressive disturbances of vision and space perception: Insights from posterior cortical atrophy | Keir Yong, UCL | |
| Dynamic computational phenotyping of human cognition | Daniel Reznik & Roey Schurr, Harvard University | |
| A prospective code for value in the serotonin system | Emerson Harkin, MPI for Biological Cybernetics, Tübingen | |
| Winter 2024/25 | Memory consolidation during sleep: Mechanisms and representations | Bernhard Staresina, University of Oxford |
| A computational perspective on causal interventions in psychiatry | Lilian Weber, University of Oxford | |
| Neurocomputational underpinnings of confidence in the context of prior beliefs | Kobe Desender, KU Leuven | |
| Dynamics of neural representation | Timothy O'Leary, University of Cambridge | |
| Learning of successor representations through on-task replay in the visual cortex | Nicolas Schuck, Universität Hamburg | |
| Cognitive neuroscience of creativity | William Orwig, Harvard University | |
| Safe and effective generative clinical AI in mental healthcare | Max Rollwage, Limbic | |
| Hippocampal and prefrontal representations underlying flexible decision-making | Mona Garvert, Julius-Maximilians-Universität Würzburg | |
| Earworms, memory consolidation, and neural replay for recently heard music | Benjamin Kubit, Princeton University | |
| The neural code underlying flexible choice and compositional reasoning | Sebastijan Veselic, University of Oxford | |
| Gamma-hydroxybutyrate as a sleep medication in depression | Francesco Bavato, University of Zurich | |
| On the alleviation of agony: Brain surgery for refractory pain | Harith Akram, UCL | |
| The "bad bot" apocalypse | Jon Roozenbeek, King's College London | |
| Parameterising inter-individual diversity in brain activity across health and Parkinson's disease | Jason Da Silva Castanheira, McGill University | |
| Summer 2025 | Psychopathology through the lens of transdiagnostic decision neuroscience | Michael Hallquist, University of North Carolina at Chapel Hil |
| Modelling strategic reconfiguration of task set in task-switching paradigms | Kevin Lloyd, MPI for Biological Cybernetics, Tübingen | |
| Episodic memory facilitates flexible decision making via access to individual events and their details | Jonathan Nicholas, New York University | |
| Correspondence between reinforcement learning phenotypes and transdiagnostic clinical symptomatology across development | Noam Goldway, Kings College London | |
| Metacontrol is guided by task structure | Wouter Kool, Washington University | |
| Understanding others: How social cognition shapes social behavior and daily social functioning in humans and non-human primates | Anita Tusche, Queen's University, Canada | |
| Internal uncertainty and abstraction in the development of social influence and social information processing across adolescence | Simon Ciranka, MPIB | |
| A corticostriatal learning model of hallucinations | Guillermo Horga, Columbia University | |
| Environmental inferences drive distinct emotions that shape behaviour | Eran Eldar, Hebrew University | |
| How metacognition is distorted in anxiety | Sucharit Katyal, Copenhagen University | |
| Memory processes supporting early skill learning | Leonardo Cohen, NIH | |
| Winter 2025/26 | Deciding under uncertainty: Cognitive mechanisms controlling choice variability and information-seeking | Marion Rouault, CNRS |
| Distinct neural mechanisms of observational learning | Pyungwon Kang, University of Zurich | |
| Meta-decision-making in hierarchical planning | Tianyuan Teng, MPI for Biological Cybernetics, Tübingen | |
| Using computational approaches to uncover the effects of psychological interventions | Isabel Berwian, UCL | |
| Language models for understanding mental health | Shir Lissak, Technion | |
| Exploring high-level cognition through large language models | Ariel Goldstein, University of Cambridge | |
| From bowel to brain: The translational journey of an anti-constipation agent into mental health | Angharad de Cates, University of Birmingham | |
| Expanding the value function: Intrinsic rewards and mood | Bastien Blain, Sorbonne University |
The strongest integrative components of the interdisciplinary and international COMP2PSYCH program are the annual meetings in which students and faculty from all COMP2PSYCH institutions participate. Table 4 shows the Academy events that took place during the reporting period.
| Event | Venue | Date |
|---|---|---|
| Academy 2023 | Berlin | 08.–10.11.2023 |
| NSAS Advanced Course in AI and Cognitive Neuroscience | San Servolo, Venice | 07.–14.09.2024 |
| Academy 2025 | London | 15.–17.11.2025 |
Furthermore, students meet on a regular basis virtually to present their upcoming, in progress, or completed research and receive in-depth feedback by students, postdocs, and faculty.

